Bluex portal11/29/2023 IF WE REQUEST, YOU IRREVOCABLY AGREE TO SIGN A NON-ELECTRONIC VERSION OF THIS AGREEMENT. YOU AGREE TO REVIEW THE AGREEMENT AND THE APPLICABLE SEPARATE SERVICE CONDITIONS PERIODICALLY TO BE AWARE OF SUCH MODIFICATIONS AND YOUR CONTINUED ACCESS OR USE OF THE SITE AND/OR THE BLUEX PAY SERVICES SHALL BE DEEMED YOUR CONCLUSIVE ACCEPTANCE OF THE MODIFIED AGREEMENT AND THE APPLICABLE SEPARATE SERVICE CONDITIONS. YOUR USE OF ANY OF THE SITES AND/OR BLUEX PAY SERVICES FOLLOWING SUCH NOTICE SHALL BE DEEMED YOUR ACCEPTANCE OF SUCH CHANGES. IF YOU DO NOT WISH TO BE BOUND BY SUCH TERMS AND CONDITIONS, YOU MAY NOT ACCESS OR USE THE SITES OR BLUEX PAY SERVICES AND SHOULD IMMEDIATELY CEASE SUCH USE.īLUEX PAY MAY MODIFY THIS AGREEMENT, INCLUDING ANY SEPARATE SERVICE CONDITIONS, AT ANY TIME, AND SUCH MODIFICATIONS SHALL BE EFFECTIVE IMMEDIATELY UPON NOTICE, WHICH MAY BE ACCOMPLISHED BY POSTING THE MODIFIED AGREEMENT OR MODIFIED SEPARATE SERVICE CONDITIONS ON THE SITE OR VIA EMAIL. BY ACCESSING OR USING THE SITES AND/OR BLUEX PAY SERVICES, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS OF THIS AGREEMENT, INCLUDING ANY APPLICABLE SEPARATE SERVICE CONDITIONS. PLEASE READ THIS AGREEMENT AND EACH APPLICABLE SEPARATE SERVICE CONDITIONS CAREFULLY BEFORE ACCESSING OR USING ANY OF THE SITES AND/OR BLUEX PAY SERVICES. ![]() By Customer using any such BlueX Pay Service, such Customer expressly agrees to the terms and conditions of the relevant Separate Service Conditions. If there are Separate Service Conditions (as defined below) applicable to any BlueX Pay Service (as defined below), Customer shall comply with all such applicable Separate Service Conditions. (sometimes referred to herein as “BlueX Pay”, “BlueX”, “we” or “us”) and Customer.īlueX Pay and Customer are referred to herein for convenience each as a “Party” and collectively as the “Parties”. ( F) Scatter plots comparing histological scores (Ishak lobular inflammation, Ishak portal inflammation, Ishak periportal hepatitis, Ishak fibrosis, and perisinusoidal fibrosis scores) with total, lobular, and portal CD45 + cell density per mm 2 for 28 IA (red diamond) and 6 IT (blue X) subjects, with Spearman’s correlations and P values.This BLUEX PAY TERMS OF SERVICE (including all exhibits, schedules and incorporated documents, including without limitation our Privacy Policy and each Separate Service Conditions collectively, the “Agreement”), is made and entered into (i) as of the date (the “Effective Date”) Customer ( “Customer” or “you”) submits your registration form on the BlueX Pay website located here (ii) by and between BlueX Trade, Inc. A single outlier with portal CD45 + immune cell density at 43,365 was not shown graphically, although it was included in calculating the Spearman’s correlation and P values (shown in red fonts for P < 0.05). ( E) Scatter plots comparing %portal/total area, ALT, HBV DNA, and age relative to total, lobular, and portal CD45 + cell density per mm 2 for 28 IA (red diamond) and 6 IT (blue X) subjects. ( D) Tissue image reproduced with portal and/or lobular location of bile ducts, hepatocytes, and immune cells by applying x/ y spatial coordinates to analyzed IMC data. ( C) Overlay of lobular CD45 –HepPar1 + (green), lobular CD45 +HepPar1 – (purple), and all portal (orange) events show HBsAg expression limited to CD45 –HepPar1 + cells, CK19 expression limited to portal cells, and CD68 expression in both lobular CD45 +HepPar1 – immune cells and portal cells. ( B) Representative contour plot and histogram overlays provide comparisons for portal (red) versus lobular (blue) detection of HepPar1, CD45, and/or CD3 expression, with expected lobular but not portal detection for HepPar1 + hepatocytes and both lobular and portal detection for CD45 + or CD3 + immune cells. Far right contour plot overlay shows that CD68 +CD45 + gate (red) is enriched for concurrent CD16/CD14 expression, compared with CD68 –CD45 + gate (blue). ( A) Acquired IMC images are visualized in representative pseudocolor plots and histogram with overlays to show that HepPar1 + events can be gated separately from CD45 + events, and that CD45 + events are enriched for immune markers (e.g., CD3, CD8, CD68).
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